Boston will be glad to see the rotation turning over with ace Garrett Crochet on the mound Wednesday. Crochet thew six shutout innings on Opening Day against the Reds, the Sox’ only win over the season.

Righthander Mike Burrows will get the ball for Houston. Burrows was roughed up in his first start of the season, allowing five runs on nine hits in a loss to the Angels on Friday.

RED SOX (1-4): Duran LF, Story SS, Yoshida DH, Contreras 1B, Abreu RF, Durbin 3B, Rafaela CF, Kiner-Falefa 2B, Wong C

Pitching: LHP Garrett Crochet (1-0, 0.00 ERA)

ASTROS (4-2): Altuve 2B, Alvarez DH, Paredes 3B, Correa SS, Walker 1B, Smith RF, Meyers CF, Matthews LF, Vazquez C

Pitching: RHP Mike Burrows (0-1, 7.94 ERA)

Time: 2:10 p.m.

TV, radio: NESN, WEEI-FM 93.7

Red Sox vs. Burrows: Roman Anthony 1-1, Jarren Duran 1-2, Caleb Durbin 0-3, Carlos Narváez 0-1, Ceddanne Rafaela 0-0, Trevor Story 1-2, Masataka Yoshida 1-2

Astros vs. Crochet: Nick Allen 1-3, Jose Altuve 3-7, Yordan Alvarez 2-3, Carlos Correa 2-7, Yainer Diaz 0-6, Jake Meyers 1-5, Isaac Paredes 2-3, Jeremy Peña 4-8, Cam Smith 1-1, Christian Vázquez 2-5, Christian Walker 1-2

Stat of the day: Crochet has struggled against the Astros in his career, going 0-3 with a 6.28 ERA in four games (three starts).

Notes: The Red Sox have eight hits in the first two games of the series — four in each game — and have 13 runs in their five games this season. Boston has struck out 54 times. “We just have to be better,” Red Sox manager Alex Cora said. … Boston struck out 13 times in the Tuesday loss. Leadoff hitter Roman Anthony fanned in each of his four at-bats. His first three strikeouts came on nine pitches. “I’m not worried,” Cora, the Astros’ bench coach in 2017, said about Anthony. “I’ve been in this building before, and supposedly it’s a good place to hit. Sometimes you don’t pick up the ball, especially early for some reason up there. I’m not saying that’s the case. I haven’t talked to him. I avoid a lot of conversations in the dugout because they’re in the middle of the battle. We’ll sit down and talk and people will talk to him and see where we’re at.” … The Astros have won four games in a row since an 0-2 start and have scored at least eight runs in each of the four wins. … Burrows has faced the Red Sox once, giving up one run on five hits in two relief innings.

Amin Touri can be reached at amin.touri@globe.com.